Khosrow Adeli, PhD, FCACB, DACBCC, FACB

 

Adjunct Professor

Phone: Organizational affiliation:
416-813-8682 University of Toronto
E-mail: Department:
khosrow.adeli@sickkids.ca Nutritional Sciences

 

About

 

Khosrow Adeli is currently a Senior Scientist in the Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, University of Toronto. He is also the head and full professor of Clinical Biochemistry at the Hospital for Sick Children and the Departments of Biochemistry, and Laboratory Medicine & Pathobiology at the University of Toronto in Toronto, Canada. He is the Director of Point of Care Testing program at the Hospital for Sick Children in Toronto.

Dr. Adeli is a fellow of the Canadian Academy of Clinical Biochemistry and a diplomate of the American Board of Clinical Biochemistry. He is currently the Editor-in-Chief of the Critical Reviews in Clinical Laboratory Sciences. Dr. Adeli served as the Editor-in-Chief of the Clinical Biochemistry journal for 7 years (1999-2006). He is an editorial board member of the Clinical Biochemist Reviews. He served (2006-2010) as the President of COMACC, the Commission on Accreditation in Clinical Chemistry, a North American organization responsible for accreditation of clinical chemistry training programs in the USA and Canada. He currently serves as the Chair of Publications and Communications Division of the International Federation of Clinical Chemistry (IFCC).


Dr. Adeli has been actively involved in both basic and clinical laboratory research since 1988 and has published over 250 articles and abstracts in the field of lipid and lipoprotein metabolism, diabetic dyslipidemia, and metabolic disorders. He has received several national and international awards for research excellence including the 2014 Distinguished Service Award of the University of Toronto, the 2011 Canadian Society of Atherosclerosis, Thrombosis and Vascular Biology (CSATVB) Scientific Excellence Award, the 2008 Merck Senior Investigator Award of the Canadian Lipoprotein Conference, the 2006 Canadian Society of Clinical Chemistry National Award for outstanding contributions to clinical chemistry, 2004 Canadian Academy of Clinical Biochemistry National Award, and the 1999 Canadian Society of Clinical Chemistry Research Excellence Award. He has also been active in clinical chemistry research and is the principal investigator of the CALIPER (Canadian Laboratory Initiative on Pediatric Reference Interval Database) project aimed at the establishment of a laboratory reference interval database for biomarkers of pediatric disease

 
MSc, Biochemistry, University of Ottawa, 1982
PhD, Biochemistry, University of Ottawa, 1986
Postdoc, Clinical Biochemistry, University of Toronto, 1988

Positions

The Hospital for Sick Children
Division Head
Clinical Biochemistry
 

Research Institute
Senior Associate Scientist
Molecular Medicine
 

University of Toronto
Professor
Departments of Biochemistry and Laboratory Medicine & Pathology

 

 
 

2017

Zhang J, Zamani M, Thiele C, Taher J, Amir Alipour M, Yao Z, Adeli K. AUP1 (Ancient Ubiquitous Protein 1) Is a key determinant of hepatic very-low-density lipoprotein assembly and secretion. arterioscler Thromb Vasc Biol. 2017Apr;37(4):633-642.

Cagman Z, Bingol Ozakpinar O, Cirakli Z, Gedikbasi A, Ay P, Colantonio D, Uras AR, Adeli K, Uras F. Reference intervals for growth arrest-specific 6 protein in adults. Scand J Clin Lab Invest. 2017 Apr;77(2):109-114.

Taher J, Farr S, Adeli K. Central nervous system regulation of hepatic lipid and lipoprotein metabolism. Curr Opin Lipidol. 2017 Feb;28(1):32-38.

2016

Tate JR, Koerbin G, Adeli K. Opinion Paper: Deriving harmonised reference intervals - Global Activities. EJIFCC. 2016 Feb 9;27(1):48-65.

Anderson LN, Maguire JL, Lebovic G, Hanley AJ, Hamilton J, Adeli K, McCrindle BW, Borkhoff CM, Parkin PC, Birken CS. Duration of fasting, serum lipids, and metabolic profile in early childhood. J Pediatr. 2016 Oct 11.

Raizman JE, Shea J, Daly CH, Karbasy K, Ariadne P, Chen Y, Henderson T, Redmond S, Silverman S, Moore AM, Adeli K. Clinical impact of improved point-of-care glucose monitoring in neonatal intensive care using Nova StatStrip: evidence for improved accuracy, better sensitivity, and reduced test utilization. Clin Biochem. 2016 Aug 1;49(12):879-84.

Loverdos I, Swan MC, Shekherdimian S, Al-Rasheed AA, Schneider R, Fish JS, Ngan BY, Adeli K, Lowe ME, Singh VP, Sevilla WM, Langer JC, Gonska T. A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition.J Pediatr Surg Case Rep. 2015 May;3(5):223-226.

Kelishadi R, Marateb HR, Mansourian M, Ardalan G, Heshmat R, Adeli K. Pediatric-specific reference intervals in a nationally representative sample of Iranian children and adolescents: the CASPIAN-III study. World J Pediatr. 2016 Aug 1;12(3):335-42.

Bashiri A, Nesan D, Tavallaee G, Sue-Chue-Lam I, Chien K, Maguire GF, Naples M, Zhang J, Magomedova L, Adeli K, Cummins CL, Ng DS. Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis. Biochim Biophys Acta. 2016 Apr 14:S1388-1981(16)30099.

Karbasy K, Lin DC, Stoianov A, Chan MK, Bevilacqua V, Chen Y, Adeli K. Pediatric reference value distributions and covariate-stratified reference intervals for 29 endocrine and special chemistry biomarkers on the Beckman Coulter immunoassay systems: a CALIPER study of healthy community children. Clin Chem Lab Med. 2016 Apr 1;54(4):643-57. 

Zamani M, Taher J, Adeli K. Complex role of autophagy in regulation of hepatic lipid and lipoprotein metabolism. J Biomed Res. 2016 Mar 3;30.

Farr S, Taher J, Adeli K. Central nervous system regulation of intestinal lipid and lipoprotein metabolism. Curr Opin Lipidol. 2016 Feb 1;27(1):1-7. 

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L. Full list of authors Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 1;12(1):1-222.

Ali SA, Al-Jazrawe M, Ma H, Whetstone H, Poon R, Farr S, Naples M, Adeli K, Alman BA. Regulation of cholesterol homeostasis by hedgehog signaling in osteoarthritic cartilage. Arthritis Rheumatol. 2016 Jan 1;68(1):127-37.

Higgins V, Chan MK, Nieuwesteeg M, Hoffman BR, Bromberg IL, Gornall D, Randell E, Adeli K. Transference of CALIPER pediatric reference intervals to biochemical assays on the Roche cobas 6000 and the Roche Modular P. Clin Biochem. 2016 Jan 1;49(1-2):139-49.

Other Detailes

 

Research Interests

  • Molecular mechanisms of dyslipidemia
  • Lipoprotein metabolism
  • ApoB gene expression
  • Animal models of obesity and insulin resistance
  • Hyperlipidemia in insulin resistance and type 2 diabetes

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